Pathogenicity and virulence of the liver flukes Fasciola hepatica and Fasciola Gigantica that cause the zoonosis Fasciolosis

R Lalor, K Cwiklinski, NED Calvani, A Dorey, S Hamon… - Virulence, 2021 - Taylor & Francis
Fasciolosis caused by the liver flukes Fasciola hepatica and Fasciola gigantica is one of the
most important neglected parasitic diseases of humans and animals. The ability of the …

Recent progress in the development of liver fluke and blood fluke vaccines

DP McManus - Vaccines, 2020 - mdpi.com
Liver flukes (Fasciola spp., Opisthorchis spp., Clonorchis sinensis) and blood flukes
(Schistosoma spp.) are parasitic helminths causing neglected tropical diseases that result in …

Complementary transcriptomic and proteomic analyses reveal the cellular and molecular processes that drive growth and development of Fasciola hepatica in the …

K Cwiklinski, MW Robinson, S Donnelly, JP Dalton - BMC genomics, 2021 - Springer
Background The major pathogenesis associated with Fasciola hepatica infection results
from the extensive tissue damage caused by the tunnelling and feeding activity of immature …

The cathepsin-like cysteine peptidases of trematodes of the genus Fasciola

K Cwiklinski, S Donnelly, O Drysdale, H Jewhurst… - Advances in …, 2019 - Elsevier
Fasciolosis caused by trematode parasites of the genus Fasciola is a global disease of
livestock, particularly cattle, sheep, water buffalo and goats. It is also a major human …

Stage-specific miRNAs regulate gene expression associated with growth, development and parasite-host interaction during the intra-mammalian migration of the …

A Ricafrente, K Cwiklinski, H Nguyen, JP Dalton… - BMC genomics, 2022 - Springer
Background MiRNAs are small non-coding RNAs that post-transcriptionally regulate gene
expression in organisms ranging from viruses to mammals. There is great relevance in …

Insights into Fasciola hepatica juveniles: crossing the fasciolosis rubicon

J González-Miguel, D Becerro-Recio… - Trends in …, 2021 - cell.com
Unraveling the molecular interactions governing the first contact between parasite and host
tissues is of paramount importance to the development of effective control strategies against …

Exploring the utility of circulating miRNAs as diagnostic biomarkers of fasciolosis

S Chowdhury, A Ricafrente, K Cwiklinski, D Sais… - Scientific Reports, 2024 - nature.com
Effective management and control of parasitic infections on farms depends on their early
detection. Traditional serological diagnostic methods for Fasciola hepatica infection in …

[HTML][HTML] Diagnosis of sheep fasciolosis caused by Fasciola hepatica using cathepsin L enzyme-linked immunosorbent assays (ELISA)

JL Corrales, K Cwiklinski, CDM Verissimo, A Dorey… - Veterinary …, 2021 - Elsevier
Fasciolosis, a global parasitic disease of agricultural livestock, is caused by the liver fluke
Fasciola hepatica. Management and strategic control of fasciolosis on farms depends on …

Complex and dynamic transcriptional changes allow the helminth Fasciola gigantica to adjust to its intermediate snail and definitive mammalian hosts

XX Zhang, K Cwiklinski, RS Hu, WB Zheng, ZA Sheng… - BMC genomics, 2019 - Springer
Background The tropical liver fluke, Fasciola gigantica causes fasciolosis, an important
disease of humans and livestock. We characterized dynamic transcriptional changes …

Omics tools enabling vaccine discovery against fasciolosis

K Cwiklinski, JP Dalton - Trends in Parasitology, 2022 - cell.com
In the past decade significant advances in our understanding of liver fluke biology have
been made through in-depth interrogation and analysis of evolving Fasciola hepatica and …