[HTML][HTML] Mitochondria: Their relevance during oocyte ageing
J van der Reest, GN Cecchino, MC Haigis… - Ageing research …, 2021 - Elsevier
The oocyte is recognised as the largest cell in mammalian species and other multicellular
organisms. Mitochondria represent a high proportion of the cytoplasm in oocytes and …
organisms. Mitochondria represent a high proportion of the cytoplasm in oocytes and …
[HTML][HTML] Mitochondrial dysfunction in aging: much progress but many unresolved questions
BAI Payne, PF Chinnery - Biochimica et Biophysica Acta (BBA) …, 2015 - Elsevier
The free radical theory of aging is almost 60 years old. As mitochondria are the principle
source of intracellular reactive oxygen species (ROS), this hypothesis suggested a central …
source of intracellular reactive oxygen species (ROS), this hypothesis suggested a central …
Detection of ultra-rare mutations by next-generation sequencing
MW Schmitt, SR Kennedy, JJ Salk… - Proceedings of the …, 2012 - National Acad Sciences
Next-generation DNA sequencing promises to revolutionize clinical medicine and basic
research. However, while this technology has the capacity to generate hundreds of billions …
research. However, while this technology has the capacity to generate hundreds of billions …
Somatic mitochondrial DNA mutations in mammalian aging
NG Larsson - Annual review of biochemistry, 2010 - annualreviews.org
Mitochondrial dysfunction is heavily implicated in the multifactorial aging process. Aging
humans have increased levels of somatic mtDNA mutations that tend to undergo clonal …
humans have increased levels of somatic mtDNA mutations that tend to undergo clonal …
Heteroplasmic mitochondrial DNA mutations in normal and tumour cells
The presence of hundreds of copies of mitochondrial DNA (mtDNA) in each human cell
poses a challenge for the complete characterization of mtDNA genomes by conventional …
poses a challenge for the complete characterization of mtDNA genomes by conventional …
Germline mitochondrial DNA mutations aggravate ageing and can impair brain development
Ageing is due to an accumulation of various types of damage,, and mitochondrial
dysfunction has long been considered to be important in this process,,,,,. There is substantial …
dysfunction has long been considered to be important in this process,,,,,. There is substantial …
Mitochondrial aging is accelerated by anti-retroviral therapy through the clonal expansion of mtDNA mutations
There is emerging evidence that people with successfully treated HIV infection age
prematurely, leading to progressive multi-organ disease, but the reasons for this are not …
prematurely, leading to progressive multi-organ disease, but the reasons for this are not …
Methods of lowering the error rate of massively parallel DNA sequencing using duplex consensus sequencing
Next Generation DNA sequencing promises to revolutionize clinical medicine and basic
research. However, while this technology has the capacity to generate hundreds of billions …
research. However, while this technology has the capacity to generate hundreds of billions …
Clonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing
LC Greaves, M Nooteboom, JL Elson… - PLoS …, 2014 - journals.plos.org
Age-related decline in the integrity of mitochondria is an important contributor to the human
ageing process. In a number of ageing stem cell populations, this decline in mitochondrial …
ageing process. In a number of ageing stem cell populations, this decline in mitochondrial …
The aging mitochondria
P Theurey, P Pizzo - Genes, 2018 - mdpi.com
Mitochondrial dysfunction is a central event in many pathologies and contributes as well to
age-related processes. However, distinguishing between primary mitochondrial dysfunction …
age-related processes. However, distinguishing between primary mitochondrial dysfunction …