Melatonin, an indoleamine hormone produced and secreted at night by pinealocytes and
extra-pineal cells, plays an important role in timing circadian rhythms (24-h internal clock) …

Prevention of neurodegenerative diseases is presently a major goal for our Society and
melatonin, an unusual phylogenetically conserved molecule present in all aerobic …

Oxidative stress has been proven to be related to the onset of a large number of health
disorders. This chemical stress is triggered by an excess of free radicals, which are …

Melatonin is a neurohormone secreted from the pineal gland and has a wide‐ranging
regulatory and neuroprotective role. It has been reported that melatonin level is disturbed in …

Pro-inflammatory systemic conditions that can cause neuroinflammation and subsequent
alterations in brain regions involved in emotional regulation have been suggested as an …

The pineal product melatonin has remarkable antioxidant properties. It is secreted during
darkness and plays a key role in various physiological responses including regulation of …

Melatonin was recently reported to be an effective free radical scavenger and antioxidant.
Melatonin is believed to scavenge the highly toxic hydroxyl radical, the peroxynitrite anion …

Melatonin is a pleiotropically acting regulator molecule, which influences numerous
physiological functions. Its secretion by the pineal gland progressively declines by age …

The worldwide prolongation of the mean life expectancy has resulted in a rapid increase of
the size of the elderly population (over the age of 60), both in numbers and as a proportion …

Parkinson's disease (PD) affects one in every 100 persons above the age of 65 years,
making it the second most common neurodegenerative disease after Alzheimer's disease …