The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …

Ion channels represent the molecular entities that give rise to the cardiac action potential,
the fundamental cellular electrical event in the heart. The concerted function of these …

The human voltage-sensitive K+ channel hERG plays a fundamental role in cardiac action
potential repolarization, effectively controlling the QT interval of the electrocardiogram …

Long‐QT syndrome (LQTS) is an arrhythmogenic disorder characterised by prolongation of
the QT interval in the electrocardiogram, which can lead to sudden cardiac death …

Human ether-à-go-go related gene (hERG) 1 channels conduct the rapid delayed rectifier
K+ current (IKr) and are essential for the repolarization of the cardiac action potential …

Human ether‐á‐go‐go related gene (hERG) potassium (K+) channels play a critical role in
cardiac action potential repolarization. This is due, in large part, to the unique gating …

Cardiomyocytes are endowed with a complex repertoire of ion channels, responsible for the
generation of action potentials (APs), travelling waves of electrical excitation, propagating …

The Kv11. 1 potassium channel, encoded by the human ether-a-go-go-related gene (hERG),
plays an essential role in the cardiac action potential. hERG blockade by small molecules …

Highlights•hERG1 potassium channels mediate repolarization of cardiac action
potentials.•hERG1 agonists alter channel gating to shorten action potential duration and QT …

The human Ether-à-go-go related gene (hERG) potassium channel is responsible for the
rapid delayed rectifier potassium current that plays a critical role in the repolarization of …