The regulation of neurons by circadian clock genes is thought to contribute to the
maintenance of neuronal functions that ultimately underlie animal behavior. However, the …

Specific metabolites have been reported to be potentially associated with Alzheimer's
disease (AD) risk. However, the comprehensive understanding of roles of metabolite …

Background Despite numerous clinical trials and decades of endeavour, there is still no
effective cure for Alzheimer's disease. Computational drug repositioning approaches may be …

SPI1, a transcription factor implicated in myeloid cell development, has emerged as a
genetic risk factor for Alzheimer's disease (AD). Recent in vivo studies reveal that Spi1 …

Cancer cells are heterogeneous, each harboring distinct molecular aberrations and are
dependent on different genes for their survival and proliferation. While successful targeted …

Available data for white matter of the brain allows to locate the normal (homeostatic),
Glioblastoma and Alzheimer's disease attractors in gene expression space and to identify …

Postnatal cortical and hippocampal mouse primary neuronal cultures are powerful and
widely-used models of neuronal activity and neurological disease. While this model is …

Alzheimer's disease (AD) is a complex multifactorial brain disorder characterised by
dementia, neurodegeneration, plaques and neurofibrillary tangles in elderly people. The …

Gene transcription refers to the process in which coding regions on the genome are copied
into mRNA molecules through complex cellular mechanisms. This process is regulated …

Advancing age is a significant factor impacting fertility in men due to age-related changes in
various quantitative and qualitative characteristics of semen. Functional genomic changes …