Advances in the biological sciences have led to an ongoing paradigm shift in toxicity testing
based on expanded application of high-throughput in vitro screening and in silico methods …

Genotoxicity data are mainly interpreted in a qualitative way, which typically results in a
binary classification of chemical entities. For more than a decade, there has been a …

The purpose of this study was to determine the toxicological and pharmacokinetic properties
of sucralose-6-acetate, a structural analog of the artificial sweetener sucralose. Sucralose-6 …

Mycotoxins, the secondary metabolites of mycotoxigenic fungi, have been found in almost all
agricultural commodities worldwide, causing enormous economic losses in livestock …

Nanomaterials (NMs) present unique challenges in safety evaluation. An international
working group, the Genetic Toxicology Technical Committee of the International Life …

Abstract In 2016, the European Commission launched the EU-ToxRisk research project to
develop and promote animal-free approaches in toxicology. The 36 partners of this …

In silico toxicology (IST) approaches to rapidly assess chemical hazard, and usage of such
methods is increasing in all applications but especially for regulatory submissions, such as …

Higher-throughput, mode-of-action-based assays provide a valuable approach to expedite
chemical evaluation for human health risk assessment. In this study, we combined the high …

Abstract The International Workshop on Genotoxicity Testing (IWGT) meets every four years
to seek consensus on difficult or conflicting approaches to genotoxicity testing based upon …

I will reflect on the role of genotoxicity in the regulation of chemical safety, summarizing the
past and current situation, and giving personal views for the future. This includes how …