Dynamin, the founding member of a family of dynamin-like proteins (DLPs) implicated in
membrane remodelling, has a critical role in endocytic membrane fission events. The use of …

Malignant cancer cells utilize their intrinsic migratory ability to invade adjacent tissues and
the vasculature, and ultimately to metastasize. Cell migration is the sum of multi-step …

Invasion of cancer cells into surrounding tissue and the vasculature is an initial step in tumor
metastasis. This requires chemotactic migration of cancer cells, steered by protrusive activity …

When migrating away from a primary tumour, cancer cells interact with and remodel the
extracellular matrix (ECM). Matrix metalloproteinases (MMPs), and in particular the …

Invadopodia are actin-rich membrane protrusions with a matrix degradation activity formed
by invasive cancer cells. We have studied the molecular mechanisms of invadopodium …

Metastatic tumor cells that actively migrate and invade surrounding tissues rely on
invadopodia to degrade extracellular matrix (ECM) barriers. Invadopodia are membrane …

Podosomes and invadopodia are unique actin-rich adhesions that establish close contact to
the substratum but can also degrade components of the extracellular matrix. Accordingly …

Metastasis is responsible for most cancer-associated deaths. Accumulating evidence based
on 3D migration models has revealed a diversity of invasive migratory schemes reflecting …

Podosomes are highly dynamic, actin-rich adhesion structures of monocyte-derived cells,
certain transformed fibroblasts and carcinoma cells and have recently also been discovered …

Invadopodia are branched actin-rich structures associated with extracellular matrix (ECM)
degradation that collectively form the invasive machinery of aggressive cancer cells …