An essential step in renal function entails the formation of an ultrafiltrate that is delivered to
the renal tubules for subsequent processing. This process, known as glomerular filtration, is …

Potassium channels are particularly important in determining the shape and duration of the
action potential, controlling the membrane potential, modulating hormone secretion …

Calcium and voltage-activated potassium (BK) channels are key actors in cell physiology,
both in neuronal and non-neuronal cells and tissues. Through negative feedback between …

The distal tubule of the mammalian kidney can be defined as the nephron segment between
the macula densa region and the cortical collecting tubule. It comprises several …

Ca2+-and voltage-gated K+ channels of large conductance (BK channels) are expressed in
a diverse variety of both excitable and inexcitable cells, with functional properties …

The aldosterone-sensitive distal nephron (ASDN) includes the late distal convoluted tubule
2, the connecting tubule (CNT) and the collecting duct. The appropriate regulation of sodium …

The kidney is a remarkable organ that accomplishes the challenge of removing waste from
the body and simultaneously regulating electrolyte and water balance. Pro-urine flows …

Hyperaldosteronism, a common cause of hypertension, is strongly connected to Na+, K+,
and Mg2+ dysregulation. Owing to its steroidal structure, aldosterone is an active …

More than two dozen types of potassium channels, with different biophysical and regulatory
properties, are expressed in the kidney, influencing renal function in many important ways …

The central goal of this overview article is to summarize recent findings in renal epithelial
transport, focusing chiefly on the connecting tubule (CNT) and the cortical collecting duct …