Highlights•Variation in both HLA and SARS-CoV-2 impact antigen presentation to T
cells.•HLA variation influences COVID-19 outcomes and T-cell responses to SARS-CoV …

Background COVID-19 is associated with several risk factors such as distinct ethnicities
(genetic ancestry), races, sexes, age, pre-existing comorbidities, smoking, and genetics. The …

Effective presentation of antigens by human leukocyte antigen (HLA) class I molecules to
CD8+ T cells is required for viral elimination and generation of long-term immunological …

The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) led to the death of millions of people worldwide and thousands more infected individuals …

HLA is crucial for appropriate immune responses in several viral infections, as well as in
severe acute respiratory syndrome coronavirus‐2 (SARS CoV‐2). The unpredictable nature …

Differences in SARS-CoV-2-specific immune responses have been observed between
individuals following natural infection or vaccination. In addition to already known factors …

Background COVID-19 is a respiratory disease caused by a novel coronavirus called as
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Detected for the first …

Background Most children and adolescents infected with the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) remain asymptomatic or develop a mild coronavirus …

The human leukocyte antigen (HLA) system is one of the most crucial host factors
influencing disease progression in bacterial and viral infections. This review provides the …

The polymorphism of the HLA system has been extensively studied in COVID‐19 infection,
however there are no data about the role of HLA on vaccine response. We report here the …