The gasdermins are a family of pore-forming proteins that have recently emerged as
executors of pyroptosis, a lytic form of cell death that is induced by the innate immune …

Pyroptosis is a proinflammatory mode of lytic cell death mediated by accumulation of plasma
membrane (PM) macropores composed of gasdermin‐family (GSDM) proteins. It facilitates …

Macrophages infected with Gram-negative bacteria expressing Type III secretion system
(T3SS) activate the NLRC4 inflammasome, resulting in Gasdermin D (GSDMD)-dependent …

Human airway and corneal epithelial cells, which are critically altered during chronic
infections mediated by Pseudomonas aeruginosa, specifically express the inflammasome …

Unconventional protein secretion (UPS) allows the release of specific leaderless proteins
independently of the classical endoplasmic reticulum (ER)-Golgi secretory pathway. While it …

Mechanisms of neutrophil involvement in severe coronavirus disease 2019 (COVID-19)
remain incompletely understood. Here, we collect longitudinal blood samples from 306 …

The immune system of multicellular organisms protects them from harmful microbes. To
establish an infection in the face of host immune responses, pathogens must evolve specific …

Pathogenic microbes invade the human body and trigger a host immune response to defend
against the infection. In response, host-adapted pathogens employ numerous virulence …

Chronic inflammation is recognized as a major risk factor for cancer and is involved in every
phase of the disease. Inflammasomes are central to the inflammatory response and play a …

Neutrophils are among the most abundant immune cells, representing about 50%− 70% of
all circulating leukocytes in humans. Neutrophils rapidly infiltrate inflamed tissues and play …