Cardiac contractility is regulated by changes in intracellular Ca concentration ([Ca2+] i).
Normal function requires that [Ca2+] i be sufficiently high in systole and low in diastole …

Calcium is an important second messenger involved in intra-and extracellular signaling
cascades and plays an essential role in cell life and death decisions. The Ca 2+ signaling …

Neuronal elements distributed throughout the cardiac nervous system, from the level of the
insular cortex to the intrinsic cardiac nervous system, are in constant communication with …

Cardiac disease is associated with deleterious emission of mitochondrial reactive oxygen
species (mito-ROS), as well as enhanced oxidation and activity of the sarcoplasmic …

Background: Cardiac ischemia/reperfusion (I/R) injury has emerged as an important
therapeutic target for ischemic heart disease, the leading cause of morbidity and mortality …

Mitochondrial-associated membranes (MAMs) are known to modulate organellar and
cellular functions and can subsequently affect pathophysiology including myocardial …

Introduction Dilated cardiomyopathy is a major cause of progressive heart failure. Utilization
of stem cell therapy offers a potential means of regenerating viable cardiac tissue. However …

Ischemic heart disease is the most common cause of lethal ventricular arrhythmias and
sudden cardiac death (SCD). In patients who are at high risk after myocardial infarction …

Ventricular arrhythmias have complex causes and mechanisms. Despite extensive
investigation involving many clinical, experimental, and computational studies, effective …

Cardiac arrhythmias can follow disruption of the normal cellular electrophysiological
processes underlying excitable activity and their tissue propagation as coherent wavefronts …