Hand-foot-and-mouth disease (HFMD) is a viral illness commonly seen in young children
under 5 years of age, characterized by typical manifestations such as oral herpes and …

Abstract Background Enterovirus A71 (EV-A71) is capable of causing hand, foot and mouth
disease (HFMD), which may lead to neurological sequelae and even death. As EV-A71 is …

Objectives: Identify the etiology of HFMD. Describe the presentation of a patient with HFMD.
Outline the management options available for HFMD. Describe interprofessional team …

Abstract Enterovirus A71 (EV-A71) is the major cause of severe hand-foot-and-mouth
diseases (HFMD), especially encephalitis and other nervous system diseases. EV-A71 …

Enterovirus 71 (EV71) is the major pathogen causing severe neurological complications and
hand, foot, and mouth disease. The intestinal mucosal immune system has a complete …

SETD3 is an essential host factor for the replication of a variety of enteroviruses that
specifically interacts with viral protease 2A. However, the interaction between SETD3 and …

Abstract Enterovirus A71 (EV‐A71) is a highly contagious virus that poses a major threat to
global health, representing the primary etiological agent for hand–foot and mouth disease …

Abstract TANK-binding kinase 1 (TBK1) is an essential protein kinase for activation of
interferon regulatory factor 3 (IRF3) and induction of the type I interferons (IFN-I). Although …

Abstract Enterovirus 71 (EV71) caused hand, foot and mouth disease (HFMD) is a serious
threat to the health of young children. Although type I interferon (IFN-I) has been proven to …

Enterovirus 71 (EV71) can invade the central nervous system (CNS) and cause neurological
disease. Accumulating evidence indicates that EV71 can directly infect neurons in the CNS …