Obesity II: establishing causal links between chemical exposures and obesity

JJ Heindel, S Howard, K Agay-Shay, JP Arrebola… - Biochemical …, 2022 - Elsevier
Obesity is a multifactorial disease with both genetic and environmental components. The
prevailing view is that obesity results from an imbalance between energy intake and …

The potential roles of post-translational modifications of PPARγ in treating diabetes

X Ji, W Zhang, L Yin, Z Shi, J Luan, L Chen, L Liu - Biomolecules, 2022 - mdpi.com
The number of patients with type 2 diabetes mellitus (T2DM), which is mainly characterized
by insulin resistance and insulin secretion deficiency, has been soaring in recent years …

Adipogenic activity of chemicals used in plastic consumer products

J Völker, F Ashcroft, Å Vedøy… - … science & technology, 2022 - ACS Publications
Bisphenols and phthalates, chemicals frequently used in plastic products, promote obesity in
cell and animal models. However, these well-known metabolism-disrupting chemicals …

Triphenyl phosphate disturbs the lipidome and induces endoplasmic reticulum stress and apoptosis in JEG-3 cells

Y Wang, J Hong, M Shi, L Guo, L Liu, H Tang, X Liu - Chemosphere, 2021 - Elsevier
Triphenyl phosphate (TPP) is a frequently used aryl organophosphate flame retardant.
Epidemiological studies have shown that TPP and its metabolite diphenyl phosphate (DPP) …

[HTML][HTML] Lipid metabolic disturbance induced by triphenyl phosphate and hydroxy metabolite in HepG2 cells

J An, J Jiang, W Tang, Y Zhong, G Ren… - Ecotoxicology and …, 2023 - Elsevier
Triphenyl phosphate (TPHP) has been widely used as flame retardants and been detected
with increasing frequency in environment. TPHP can transform into mono-hydroxylated …

Proteomic and phosphoproteomic profiling in heart failure with preserved ejection fraction (HFpEF)

M Valero-Muñoz, EL Saw, RM Hekman… - Frontiers in …, 2022 - frontiersin.org
Although the prevalence of heart failure with preserved ejection fraction (HFpEF) is
increasing, evidence-based therapies for HFpEF remain limited, likely due to an incomplete …

Adipogenic Effects of Cresyl Diphenyl Phosphate (Triphenyl Phosphate Alternative) through Peroxisome Proliferator-Activated Receptor Gamma Pathway: A …

L Sun, X Liu, J Du, H Yang, Y Lin, D Yu… - Environmental …, 2024 - ACS Publications
Cresyl diphenyl phosphate (CDP), a novel organophosphate ester (OPE), has been
detected in various environmental and human samples. However, there is very limited …

Remodeling on adipocytic physiology of organophosphorus esters in mature adipocytes

Y Liu, Y Le, M Xu, W Wang, H Chen, Q Zhang… - Environmental …, 2022 - Elsevier
The emerging endocrine disruption chemicals organophosphate esters (OPEs) pose high
risk of metabolic disruption. However, limited information is available on physiological …

Organophosphorus Flame Retardants and Metabolic Disruption: An in Silico, in Vitro, and in Vivo Study Focusing on Adiponectin Receptors

Y Liu, X Ma, Y Le, J Feng, M Xu… - Environmental Health …, 2024 - ehp.niehs.nih.gov
Background: Environmental chemical exposures have been associated with metabolic
outcomes, and typically, their binding to nuclear hormone receptors is considered the …

[HTML][HTML] Cresyl diphenyl phosphate (a novel organophosphate ester) induces hepatic steatosis by directly binding to liver X receptor α: From molecule action to risk …

X Liu, L Sun, Y Lin, J Du, H Yang, C Li - Environment International, 2024 - Elsevier
Cresyl diphenyl phosphate (CDP), a novel organophosphate ester (OPE), has been
increasingly detected in various environmental and human samples. However, its toxicity …