Inflammation is a biological response of the immune system that can be triggered by a
variety of factors, including pathogens, damaged cells and toxic compounds. These factors …

Cardiovascular and metabolic diseases (CVMD) are the leading causes of death worldwide,
underscoring the urgent necessity to develop new pharmacotherapies. Berberine (BBR) is …

In this scientific statement from the American Heart Association, experts in the field of
cardiomyopathy (heart muscle disease) in children address 2 issues: the most current …

Cardiac remodeling is defined as a group of molecular, cellular and interstitial changes that
manifest clinically as changes in size, mass, geometry and function of the heart after injury …

Despite significant improvements in reperfusion strategies, acute coronary syndromes all too
often culminate in a myocardial infarction (MI). The consequent MI can, in turn, lead to …

Current therapies for heart failure after myocardial infarction are limited and non-curative.
Although regenerative approaches are receiving significant attention, clinical efforts that …

Human induced pluripotent stem cells (hiPSCs) hold promise for myocardial repair following
injury, but preclinical studies in large animal models are required to determine optimal cell …

Fibroblasts do not only serve as matrix-producing reparative cells, but exhibit a wide range
of functions in inflammatory and immune responses, angiogenesis and neoplasia. The adult …

Mesenchymal stem cells (MSCs) are broadly distributed cells that retain postnatal capacity
for self-renewal and multilineage differentiation. MSCs evade immune detection, secrete an …

Modification of histones is one of the important mechanisms of epigenetics, in which genetic
control is determined by factors other than an individual's DNA sequence. Sirtuin family …