Cellular development, morphology and function are governed by precise patterns of gene
expression. These are established by the coordinated action of genomic regulatory …

Developmental progression is driven by specific spatiotemporal domains of gene
expression, which give rise to stereotypically patterned embryos even in the presence of …

Transcriptional enhancers act as docking stations for combinations of transcription factors
and thereby regulate spatiotemporal activation of their target genes. It has been a long …

Over the last decade, the zebrafish has entered the field of cardiovascular research as a
new model organism. This is largely due to a number of highly successful small-and large …

A large part of the mammalian genome is transcribed into noncoding RNAs. Long
noncoding RNAs (lncRNAs) have emerged as critical epigenetic regulators of gene …

We describe a new computational method for estimating the probability that a point mutation
at each position in a genome will influence fitness. These'fitness consequence'(fitCons) …

Accurate control of tissue-specific gene expression plays a pivotal role in heart
development, but few cardiac transcriptional enhancers have thus far been identified …

A series of reports over the last few years have indicated that a much larger portion of the
mammalian genome is transcribed than can be accounted for by currently annotated genes …

Previous studies have shown that copy-number variants (CNVs) contribute to the risk of
complex developmental phenotypes. However, the contribution of global CNV burden to the …

Despite continual progress in the cataloging of vertebrate regulatory elements, little is known
about their organization and regulatory architecture. Here we describe a massively parallel …