Osteoporotic fractures are prevalent in society, and their incidence appears to be increasing
as the worldwide population ages. However, conventional bone repair materials hardly …

Adequate bone regeneration has been difficult to achieve at segmental bone defects caused
by disease. The surface structure and phase composition of calcium phosphate bioceramic …

While most bone defects can be repaired spontaneously, the healing process can be
complicated due to insufficient bone regeneration when osteoporosis occurs. Synthetic …

Reconstruction of osteoporotic bone defects is a clinical problem that continues to inspire
the design of new materials. Methods: In this work, bioceramics composed of strontium (Sr) …

Adequate bone substitutes osseointegration has been difficult to achieve in osteoporosis.
Hydroxyapatite of the osteoporotic bone, secreted by pathologic osteoblasts, had a smaller …

Animal models are unavoidable and indispensable research tools in the fields of bone
tissue engineering and experimental orthopaedics. The fact that there is not ideal animal …

It is a particularly critical challenge to achieve enough bone regeneration in osteoporotic
fractures with bone defects. In the present study, we designed a micro-/nano-structured …

Osteoporotic bone defect repair using synthetic biomaterial-based strategies is promising
but remains challenging as it requires superior efficient osteogenic effects. Due to the strong …

Ibandronate (IBN) and pulsed electromagnetic field (PEMF) have each shown positive
effects for treating osteoporosis, but no study has evaluated the relative effects of these …

Porous biphasic calcium phosphate bioceramic (BCP) possesses osteoinductivity to induce
the osteoblastic commitment of mesenchymal stem cells (MSCs) and ectopic bone …