Metformin is a first-line drug for the treatment of individuals with type 2 diabetes, yet its
precise mechanism of action remains unclear. Metformin exerts its antihyperglycemic action …

Abstract Aims Glucagon‐like peptide‐1 (GLP‐1) and gastric inhibitory polypeptide (GIP) are
important insulinotropic hormones that enhance the insulin secretory response to feeding …

Abstract Background and Objective Metformin is contraindicated in patients with renal
impairment; however, there is poor adherence to current dosing guidelines. In addition, the …

Background: Metformin (Mf)(N, N'-Dimethylbiguanide) is used as the first-line medication for
treating diabetes mellitus type II. It is also considered as a “gold standard” treatment for …

In this study, a simple, rapid and sensitive HPLC method with UV detection is described for
determination of metformin in plasma samples from bioequivalence assays. Sample …

Background Lactic acidosis is an adverse event associated with metformin usage. Patients
with metformin-associated lactic acidosis (MALA), however, often have other conditions …

This study presents the optimization of a simple HPLC-UV method for the determination of
metformin in human plasma. Ion pair separation followed by UV detection was performed on …

A simple and rapid liquid chromatography/tandem mass spectrometry (LC–MS/MS) method
has been developed and validated for the simultaneous quantitation of antidiabetic drugs …

An assay based on cation exchange solid-phase extraction and liquid chromatography-
tandem mass spectrometry (LC/MS/MS) has been developed for the quantitative …

A rapid and simple method for quantitation of metformin (MET) in human plasma by HPLC–
MS/MS was developed and validated. The sample preparation consists of plasma …