Systematic review: T-cell–based assays for the diagnosis of latent tuberculosis infection: an update

M Pai, A Zwerling, D Menzies - Annals of internal medicine, 2008 - acpjournals.org
Background: Interferon-γ–release assays (IGRAs) are alternatives to the tuberculin skin test
(TST). A recent meta-analysis showed that IGRAs have high specificity, even among …

Specific immune-based diagnosis of tuberculosis

P Andersen, ME Munk, JM Pollock, TM Doherty - The Lancet, 2000 - thelancet.com
Current diagnostic tests for tuberculosis based on tuberculin have poor specificity, and both
BCG vaccination and exposure to non-tuberculosis mycobacteria produce a response …

Meta-analysis: new tests for the diagnosis of latent tuberculosis infection: areas of uncertainty and recommendations for research

D Menzies, M Pai, G Comstock - Annals of internal medicine, 2007 - acpjournals.org
Background: Until recently, the tuberculin skin test was the only test for detecting latent
tuberculosis (TB) infection, but 2 ex vivo interferon-γ release assays (IGRAs) are now …

Interferon-γ assays in the immunodiagnosis of tuberculosis: a systematic review

M Pai, LW Riley, JM Colford - The Lancet infectious diseases, 2004 - thelancet.com
A major challenge in tuberculosis control is the diagnosis and treatment of latent
tuberculosis infection. Until recently, there were no alternatives to the tuberculin skin test …

A systematic review of rapid diagnostic tests for the detection of tuberculosis infection

J Dinnes, J Deeks, H Kunst, A Gibson… - Health technology …, 2007 - wrap.warwick.ac.uk
Objectives To evaluate the effectiveness of available rapid diagnostic tests to identify
tuberculosis (TB) infection. Data sources Electronic databases were searched from 1975 to …

Comparison of a whole-blood interferon γ assay with tuberculin skin testing for detecting latent Mycobacterium tuberculosis infection

GH Mazurek, PA LoBue, CL Daley, J Bernardo… - Jama, 2001 - jamanetwork.com
ContextIdentifying persons with latent tuberculosis infection (LTBI) is crucial to the goal of TB
elimination. A whole-blood interferon γ (IFN-γ) assay, the QuantiFERON-TB test, is a …

Use of synthetic peptides derived from the antigens ESAT-6 and CFP-10 for differential diagnosis of bovine tuberculosis in cattle

HM Vordermeier, A Whelan, PJ Cockle… - Clinical Diagnostic …, 2001 - Am Soc Microbiol
ABSTRACT In Great Britain an independent scientific review for the government has
concluded that the development of a cattle vaccine against Mycobacterium bovis infection …

Immune Responses to the Mycobacterium tuberculosis-Specific Antigen ESAT-6 Signal Subclinical Infection among Contacts of Tuberculosis Patients

TM Doherty, A Demissie, J Olobo… - Journal of clinical …, 2002 - Am Soc Microbiol
Diagnosis of latent Mycobacterium tuberculosis infection is considered essential for
tuberculosis control but is hampered by the lack of specific reagents. We report that strong …

Latent Tuberculosis in HIV positive, diagnosed by the M. Tuberculosis Specific Interferon-γ test

I Brock, M Ruhwald, B Lundgren, H Westh… - Respiratory …, 2006 - Springer
Background Although tuberculosis (TB) is a minor problem in Denmark, severe and
complicated cases occur in HIV positive. Since the new M. tuberculosis specific test for latent …

Prospective Evaluation of a Whole-Blood Test Using Mycobacterium tuberculosis-Specific Antigens ESAT-6 and CFP-10 for Diagnosis of Active Tuberculosis

P Ravn, ME Munk, AB Andersen… - Clinical and Vaccine …, 2005 - Am Soc Microbiol
ABSTRACT A new immunodiagnostic test based on the Mycobacterium tuberculosis-specific
antigens CFP-10/ESAT-6 (QFT-RD1) has been launched as an aid in the diagnosis of latent …