Mono-and biallelic variant effects on disease at biobank scale
Identifying causal factors for Mendelian and common diseases is an ongoing challenge in
medical genetics. Population bottleneck events, such as those that occurred in the history of …
medical genetics. Population bottleneck events, such as those that occurred in the history of …
Dominance and multi-locus interaction
J Li, C Bank - Trends in Genetics, 2024 - cell.com
Dominance is usually considered a constant value that describes the relative difference in
fitness or phenotype between heterozygotes and the average of homozygotes at a focal …
fitness or phenotype between heterozygotes and the average of homozygotes at a focal …
Screening embryos for polygenic disease risk: a review of epidemiological, clinical, and ethical considerations
A Capalbo, G de Wert, H Mertes… - Human reproduction …, 2024 - academic.oup.com
BACKGROUND The genetic composition of embryos generated by in vitro fertilization (IVF)
can be examined with preimplantation genetic testing (PGT). Until recently, PGT was limited …
can be examined with preimplantation genetic testing (PGT). Until recently, PGT was limited …
Exposure to Air Pollution, Genetic Susceptibility, and Psoriasis Risk in the UK
J Wu, Y Ma, J Yang, Y Tian - JAMA Network Open, 2024 - jamanetwork.com
Importance Psoriasis is a common autoinflammatory disease influenced by complex
interactions between environmental and genetic factors. The influence of long-term air …
interactions between environmental and genetic factors. The influence of long-term air …
A polygenic score method boosted by non-additive models
Dominance heritability in complex traits has received increasing recognition. However, most
polygenic score (PGS) approaches do not incorporate non-additive effects. Here, we present …
polygenic score (PGS) approaches do not incorporate non-additive effects. Here, we present …
Discovering non-additive heritability using additive GWAS summary statistics
LD score regression (LDSC) is a method to estimate narrow-sense heritability from genome-
wide association study (GWAS) summary statistics alone, making it a fast and popular …
wide association study (GWAS) summary statistics alone, making it a fast and popular …
Sibling Differences in Genetic Propensity for Education: How do Parents React?
A Sanz-de-Galdeano, A Terskaya - Review of Economics and …, 2023 - direct.mit.edu
We take advantage of recent advances in genomics to revisit a classic question in
economics: how do parents respond to children's endowments and to sibling differences in …
economics: how do parents respond to children's endowments and to sibling differences in …
Cross-ancestry analyses identify new genetic loci associated with 25-hydroxyvitamin D
Vitamin D status–a complex trait influenced by environmental and genetic factors–is tightly
associated with skin colour and ancestry. Yet very few studies have investigated the genetic …
associated with skin colour and ancestry. Yet very few studies have investigated the genetic …
Dominance is common in mammals and is associated with trans-acting gene expression and alternative splicing
Background Dominance and other non-additive genetic effects arise from the interaction
between alleles, and historically these phenomena play a major role in quantitative …
between alleles, and historically these phenomena play a major role in quantitative …
Accounting for statistical non-additive interactions enables the recovery of missing heritability from GWAS summary statistics
LD score regression (LDSC) is a method to estimate narrow-sense heritability from genome-
wide association study (GWAS) summary statistics alone, making it a fast and popular …
wide association study (GWAS) summary statistics alone, making it a fast and popular …