Metastasis is a major contributor to cancer-associated deaths. It is characterized by a
multistep process that occurs through the acquisition of molecular and phenotypic changes …

Evidence accumulated over the past decade shows that long non-coding RNAs (lncRNAs)
are widely expressed and have key roles in gene regulation. Recent studies have begun to …

A diverse catalog of long noncoding RNAs (lncRNAs), which lack protein-coding potential,
are transcribed from the mammalian genome. They are emerging as important regulators in …

With the development of proteomics and epigenetics, a large number of RNA‐binding
proteins (RBPs) have been discovered in recent years, and the interaction between long …

The tumor microenvironment is proposed to contribute substantially to the progression of
cancers, including breast cancer. Cancer‐associated fibroblasts (CAFs) are the most …

Cancer is difficult to cure due to frequent metastasis, and developing effective therapeutic
approaches to treat cancer is urgently important. Long non-coding RNAs (lncRNAs) have …

For decades, research into cancer biology focused on the involvement of protein-coding
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …

Cancer ranks as one of the deadliest diseases worldwide. The high mortality rate associated
with cancer is partially due to the lack of reliable early detection methods and/or inaccurate …

Over the last decade, it has been increasingly demonstrated that the genomes of many
species are pervasively transcribed, resulting in the production of numerous long noncoding …

MALAT1 has previously been described as a metastasis-promoting long noncoding RNA
(lncRNA). We show here, however, that targeted inactivation of the Malat1 gene in a …