Myocardin (MYOCD) is a potent transcriptional coactivator that functions primarily in cardiac
muscle and smooth muscle through direct contacts with serum response factor (SRF) over …

VSMC s in resistance arteries and arterioles express a diverse array of KV channels with
members of the KV 1, KV 2 and KV 7 families being particularly important. Members of the …

Potassium channels importantly contribute to the regulation of vascular smooth muscle
(VSM) contraction and growth. They are the dominant ion conductance of the VSM cell …

Ion channels allow the flux of specific ions across biological membranes, thereby
determining ion homeostasis within the cells. Voltage-gated potassium-selective ion …

Voltage-dependent K+ channels (Kv) are involved in a number of physiological processes,
including immunomodulation, cell volume regulation, apoptosis as well as differentiation …

Kv1. 3 channels are involved in the switch to proliferation of normally quiescent cells, being
implicated in the control of cell cycle in many different cell types and in many different ways …

The voltage-gated potassium channel KV 1.3 is a well-established therapeutic target for a
range of autoimmune diseases, in addition to being the site of action of many venom-derived …

The fully differentiated medial vascular smooth muscle cells (VSMCs) of mature vessels
keep quiescent and contractile. However, VSMC can exhibit the plasticity in phenotype …

Obesity is an epidemic, calling for innovative and reliable pharmacological strategies. Here,
we show that ShK-186, a selective and potent blocker of the voltage-gated Kv1. 3 channel …

Objective—Phenotypic modulation of vascular smooth muscle cells has been associated
with a decreased expression of all voltage-dependent potassium channel (Kv) 1 channel …