Reactive oxygen species (ROS), a group of highly reactive ions and molecules, are
increasingly being appreciated as powerful signaling molecules involved in the regulation of …

Autophagy, also known as macroautophagy, is a tightly regulated process involved in the
stress responses, such as starvation. It is a vacuolar, lysosomal pathway for the degradation …

Pyroptosis, a form of programmed cell death (PCD), has garnered increasing attention as it
relates to innate immunity and diseases. However, the involvement of pyroptosis in the …

As a widespread and ubiquitous pollutant of marine ecosystems, microplastic has the
potential to become an emerging global threat for aquatic organisms. The present study …

Background: Oxidative stress from elevated reactive oxygen species (ROS) has been
reported to induce cell apoptosis and may provide a means to target cancer cells. Celastrol …

Obesity symbolizes a major public health problem. Overweight and obesity are associated to
the occurrence of the metabolic syndrome and to adipose tissue dysfunction. The adipose …

Autophagy is an important cellular self-digestion and recycling pathway that helps in
maintaining cellular homeostasis. Dysregulation at various steps of the autophagic and …

Celastrol, a natural bioactive ingredient derived from Tripterygium wilfordii Hook F, exhibits
significant broad-spectrum anticancer activities for the treatment of a variety of cancers …

Rationale: Excessive Ang II (angiotensin II) levels lead to a profibrotic and hypertrophic
milieu that produces deleterious remodeling and dysfunction in hypertension-associated …

Cancer is one of the leading causes of death globally. The development of drug resistance
is the main contributor to cancer-related mortality. Cancer cells exploit multiple mechanisms …