Systemic combination chemotherapy and intrathecal chemotherapy markedly increased the
survival rate of children with ALL. In the past two decades, the use of minimal (measurable) …

Cure rates for acute lymphoblastic leukemia (ALL), the most common childhood cancer have
steadily improved over the past five decades. This is due to intensifying systemic therapy …

Acute lymphoblastic leukemia (ALL) with fusions of ABL-class tyrosine kinase genes other
than BCR:: ABL1 occurs in∼ 3% of children with ALL. The tyrosine kinase genes involved in …

Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) represents a
high-risk B-lineage ALL subtype characterized by adverse clinical features and poor relapse …

Background The increasing volume and intricacy of sequencing data, along with other
clinical and diagnostic data, like drug responses and measurable residual disease, creates …

Radiotherapy (RT) remains a primary treatment modality for glioblastoma (GBM), but it
induces cellular senescence and is strongly implicated in GBM progression and RT-related …

Exposure to benzene causes acute myelosuppression and other hematologic disorders.
However, the detailed mechanism by which benzene exerts its severe hematotoxicity and …

The incorporation of tyrosine kinase inhibitors (TKIs) in the treatment of Philadelphia
chromosome–positive acute lymphoblastic leukemia (Ph+ ALL) led to significant …

No clear benefit of preventive cranial radiotherapy in childhood Philadelphia-positive acute
lymphoblastic leukemia: a retrospective analysis of the EsPhALL2010 study - PMC Skip to main …

Treatment-related mortality is a dreadful complication of childhood cancer treatment. During
2003–2012 it was estimated to affect 3.9–4.6% of children diagnosed with cancer in high …