Brain heterogeneity in schizophrenia and its association with polygenic risk

D Alnæs, T Kaufmann, D Van Der Meer… - JAMA …, 2019 - jamanetwork.com
Importance Between-individual variability in brain structure is determined by gene-
environment interactions, possibly reflecting differential sensitivity to environmental and …

Genetic association between schizophrenia and cortical brain surface area and thickness

W Cheng, O Frei, D van der Meer, Y Wang… - JAMA …, 2021 - jamanetwork.com
Importance Schizophrenia is a complex heritable disorder associated with many genetic
variants, each with a small effect. While cortical differences between patients with …

Genetic architecture of the white matter connectome of the human brain

Z Sha, D Schijven, SE Fisher, C Francks - Science advances, 2023 - science.org
White matter tracts form the structural basis of large-scale brain networks. We applied brain-
wide tractography to diffusion images from 30,810 adults (UK Biobank) and found significant …

[HTML][HTML] Polygenic risk for schizophrenia, major depression, and post-traumatic stress disorder and hippocampal subregion volumes in middle childhood

JG Pine, SE Paul, E Johnson, R Bogdan, S Kandala… - Behavior genetics, 2023 - Springer
Studies demonstrate that individuals with diagnoses for Major Depressive Disorder (MDD),
Post-traumatic Stress Disorder (PTSD), and Schizophrenia (SCZ) may exhibit smaller …

[HTML][HTML] Shared and unique heritability of hippocampal subregion volumes in children and adults

JG Pine, A Agrawal, R Bogdan, S Kandala, S Cooper… - NeuroImage, 2024 - Elsevier
Behavioral genetic analyses have not demonstrated robust, unique, genetic correlates of
hippocampal subregion volume. Genetic differentiation of hippocampal longitudinal axis …

FPLS-DC: functional partial least squares through distance covariance for imaging genetics

W Pan, Y Shan, C Li, S Huang, T Li, Y Li, H Zhu - Bioinformatics, 2024 - academic.oup.com
Motivation Imaging genetics integrates imaging and genetic techniques to examine how
genetic variations influence the function and structure of organs like the brain or heart …

Genetic predictors of hippocampal subfield volume in PTSD cases and trauma-exposed controls

RA Morey, ME Garrett, JS Stevens… - European Journal of …, 2020 - Taylor & Francis
Behavioural, structural, and functional neuroimaging have implicated the hippocampus as a
critical brain region in posttraumatic stress disorder (PTSD) pathogenesis. Recent work in a …

Genetic specificity of hippocampal subfield volumes, relative to hippocampal formation, identified in 2148 young adult twins and siblings

NK Hansell, LT Strike, L van Eijk… - Twin Research and …, 2022 - cambridge.org
The hippocampus is a complex brain structure with key roles in cognitive and emotional
processing and with subregion abnormalities associated with a range of disorders and …