Replication perturbations activate DNA damage tolerance (DDT) pathways, which are
crucial to promote replication completion and to prevent fork breakage, a leading cause of …

Post-translational modification by Small Ubiquitin-like Modifier (SUMO) proteins regulates
numerous cellular processes. This modification involves the covalent and reversible …

The essential functions of the conserved Smc5/6 complex remain elusive. To uncover its
roles in genome maintenance, we established Saccharomyces cerevisiae cell-cycle …

The post-translational modification of proteins by SUMO is crucial for cellular viability and
mammalian development in part due to the contribution of SUMOylation to genome …

Accurate transmission of the genetic information requires complete duplication of the
chromosomal DNA each cell division cycle. However, the idea that replication forks would …

Highlights•DNA damage tolerance (DDT) modes are temporally separated within the cell-
cycle.•DNA bending and cohesion facilitate recombination-mediated DDT during …

The complete and faithful duplication of the genome is an essential prerequisite for
proliferating cells to maintain genome integrity. This objective is greatly challenged by DNA …

Complete and faithful duplication of its entire genetic material is one of the essential
prerequisites for a proliferating cell to maintain genome stability. Yet, during replication DNA …

Break-induced replication (BIR) is a DNA double-strand break repair pathway that leads to
genomic instabilities similar to those observed in cancer. BIR proceeds by a migrating …

Accurate completion of genome duplication is threatened by multiple factors that hamper the
advance and stability of the replication forks. Cells need to tolerate many of these blocking …