The urothelium, which lines the inner surface of the renal pelvis, the ureters, and the urinary
bladder, not only forms a high-resistance barrier to ion, solute and water flux, and …

Capsaicin, the pungent ingredient of the hot chili pepper, is known to act on the transient
receptor potential cation channel vanilloid subfamily member 1 (TRPV1). TRPV1 is involved …

Introduction The normal bladder functions, storage and elimination of urine, are based on a
coordinated interplay of reciprocal contraction and relaxation of the bladder and the outflow …

The uroepithelium sits at the interface between the urinary space and underlying tissues,
where it forms a high-resistance barrier to ion, solute, and water flux, as well as pathogens …

The lower urinary tract constitutes a functional unit controlled by a complex interplay
between the central and peripheral nervous systems and local regulatory factors. In the …

BACKGROUND: Treatment of human bladder overactivity with intradetrusor Botulinum-A
neurotoxin (BoNT/A) injections temporarily blocks the presynaptic release of acetylcholine …

Purinergic signalling is involved in a number of physiological and pathophysiological
activities in the lower urinary tract. In the bladder of laboratory animals there is …

This review deals with individual components regulating the neural control of the urinary
bladder. This article will focus on factors and processes involved in the two modes of …

The urothelium was once purported to be a passive membrane. However, a growing body of
evidence indicates that the urothelium actively participates in sensory functions, expressing …

Transient receptor potential vanilloid 1 (TRPV1) is an ion channel present on sensory
neurons which is activated by heat, protons, capsaicin and a variety of endogenous lipids …