Cardiac fibrosis is a critical pathophysiological process that occurs with diverse types of
cardiac injury. Lipids are the most important bioenergy substrates for maintaining optimal …

Background Transcriptomic studies have contributed to fundamental knowledge of
myocardial remodeling in human heart failure (HF). However, the key HF genes reported are …

Cardiac fibrosis and myocyte hypertrophy play contributory roles in the progression of
diseases such as heart Failure (HF) through what is collectively termed cardiac remodelling …

Oxo-6, 8, 11, 14-eicosatetraenoic acid (5-oxo-ETE) is an arachidonic acid metabolite
produced along with leukotrienes via the 5-lipoxygenase pathway. Metabolomics studies …

Cardiac fibrosis is a cause of morbidity and mortality in people with heart disease. Anti-
fibrosis treatment is a significant therapy for heart disease, but there is still no thorough …

Obesity is an expanding global public health problem and a leading cause of metabolic
disorders. The hepatokine Fetuin B participates in regulating insulin resistance, glucose …

Selenium (Se) is considered to have antioxidant properties, which are beneficial for heart
condition. Hyperhomocysteinemia (HHCY) has been suggested to potentially lead to heart …

Sphingosine‐1‐phosphate (S1P) is a bioactive sphingolipid found in all eukaryotic cells.
Although it may function as an intracellular second messenger, most of its effects are …

Introduction Dermatomyositis (DM) is an idiopathic inflammatory myopathy. Because of
clinical heterogeneity, the metabolite profile of DM patients with different myositis-specific …

Background: Inflammation might play a critical role in the pathogenesis and progression of
Philadelphia-negative myeloproliferative neoplasms (Ph− MPNs) with elevated inflammatory …