[HTML][HTML] Deciphering drug resistance in Mycobacterium tuberculosis using whole-genome sequencing: progress, promise, and challenges

KA Cohen, AL Manson, CA Desjardins, T Abeel… - Genome medicine, 2019 - Springer
Tuberculosis (TB) is a global infectious threat that is intensified by an increasing incidence of
highly drug-resistant disease. Whole-genome sequencing (WGS) studies of Mycobacterium …

Highly transmitted M. tuberculosis strains are more likely to evolve MDR/XDR and cause outbreaks, but what makes them highly transmitted?

AKA Emane, X Guo, HE Takiff, S Liu - Tuberculosis, 2021 - Elsevier
Abstract Multi-Drug-Resistant strains of Mycobacterium tuberculosis (MDR-TB) are a serious
obstacle to global TB eradication. While most MDR-TB strains are infrequently transmitted, a …

Citywide transmission of multidrug-resistant tuberculosis under China's rapid urbanization: a retrospective population-based genomic spatial epidemiological study

Q Jiang, Q Liu, L Ji, J Li, Y Zeng, L Meng… - Clinical Infectious …, 2020 - academic.oup.com
Background Population movement could extend multidrug-resistant tuberculosis (MDR-TB)
transmission and complicate its global prevalence. We sought to identify the high-risk …

Genotype–Phenotype Characterization of Serial Mycobacterium tuberculosis Isolates in Bedaquiline-Resistant Tuberculosis

TS Brown, L Tang, SV Omar, L Joseph… - Clinical Infectious …, 2024 - academic.oup.com
Background Emerging resistance to bedaquiline (BDQ) threatens to undermine advances in
the treatment of drug-resistant tuberculosis (DRTB). Characterizing serial Mycobacterium …

[HTML][HTML] Diseases spectrum in the field of spatiotemporal patterns mining of infectious diseases epidemics: A bibliometric and content analysis

W Lu, H Ren - Frontiers in Public Health, 2023 - frontiersin.org
Numerous investigations of the spatiotemporal patterns of infectious disease epidemics,
their potential influences, and their driving mechanisms have greatly contributed to effective …

The epidemiology, transmission, diagnosis, and management of drug-resistant tuberculosis—lessons from the South African experience

K Naidoo, R Perumal, H Cox, B Mathema… - The Lancet Infectious …, 2024 - thelancet.com
Drug-resistant tuberculosis (DR-TB) threatens to derail tuberculosis control efforts,
particularly in Africa where the disease remains out of control. The dogma that DR-TB …

Connecting the dots: understanding how human mobility shapes TB epidemics

TS Brown, DA Robinson, CO Buckee, B Mathema - Trends in microbiology, 2022 - cell.com
Tuberculosis (TB) remains a leading infectious cause of death worldwide. Reducing TB
infections and TB-related deaths rests ultimately on stopping forward transmission from …

[HTML][HTML] Spatial Distribution of Drug-Resistant Mycobacterium tuberculosis Infections in Rural Eastern Cape Province of South Africa

LM Faye, MC Hosu, S Vasaikar, A Dippenaar… - Pathogens, 2023 - mdpi.com
Tuberculosis (TB), an infectious airborne disease caused by Mycobacterium tuberculosis
(Mtb), is a serious public health threat reported as the leading cause of morbidity and …

[HTML][HTML] Spatial co-clustering of tuberculosis and hiv in Ethiopia

LL Gemechu, LK Debusho - Diseases, 2022 - mdpi.com
Background: Tuberculosis (TB) and HIV are epidemiologically associated, and their co-
dynamics suggest that the two diseases are directly related at the population level and …

Pre-detection history of extensively drug-resistant tuberculosis in KwaZulu-Natal, South Africa

TS Brown, L Challagundla, EH Baugh… - Proceedings of the …, 2019 - National Acad Sciences
Antimicrobial-resistant (AMR) infections pose a major threat to global public health. Similar
to other AMR pathogens, both historical and ongoing drug-resistant tuberculosis (TB) …