Lung transplantation has been established worldwide as the last treatment for end-stage
respiratory failure. However, ischemia–reperfusion injury (IRI) inevitably occurs after lung …

Lung transplantation is a life-saving treatment for patients with end stage lung disease. The
imbalance between lung graft supply and recipients has been a serious issue and barrier to …

Lung transplantation is an established life-saving intervention for patients with end-stage
lung diseases. The success of lung transplantation mainly depends on the quality and …

Lung transplantation was the ultimate method to treat the end-stage benign lung diseases.
Although the lung transplantation has been increasing quickly in the past 30 years, the …

There is a severe shortage in the availability of donor organs for lung transplantation. Novel
strategies are needed to optimize usage of available organs to address the growing global …

Background Donation after circulatory death (DCD) has the potential to significantly alleviate
the shortage of transplantable lungs. We report our initial experience with the use of portable …

Normothermic ex vivo lung perfusion (EVLP) allows for assessment and reconditioning of
donor lungs. Although a leukocyte filter (LF) is routinely incorporated into the EVLP circuit; its …

Background. Necroptosis, one of the types of regulated necrosis, causes ischemia–
reperfusion (IR) lung injury. N-acetyl-leucyl-leucyl-norleucinal (ALLN), a calpain inhibitor, is …

Ex vivo lung perfusion (EVLP), a technique in which isolated lungs are continually ventilated
and perfused at normothermic temperature, is emerging as a promising platform to optimize …

Although lung transplant remains the only option for patients suffering from end-stage lung
failure, donor supply is insufficient to meet demand. Static cold preservation is the most …