Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …

Autosomal-dominant polycystic kidney disease (ADPKD) is a disease of defective tissue
homeostasis resulting in active remodeling of nephrons and bile ducts to form fluid-filled …

Renal disease represents a major health problem that often results in end-stage renal failure
necessitating dialysis and eventually transplantation. Historically these diseases have been …

Abstract Dysregulation of polycystin-1 (PC1) leads to autosomal dominant polycystic kidney
disease (ADPKD), a disorder characterized by the formation of multiple bilateral renal cysts …

Chronic Kidney Disease (CKD) is a growing worldwide problem, leading to end-stage renal
disease (ESRD). Current treatments for ESRD include haemodialysis and kidney …

In vitro generation of three-dimensional (3D) biological tissues and organ-like structures is a
promising strategy to study and closely model complex aspects of the molecular, cellular …

Mutations in polycystin 1 and 2 (PC1 and PC2) cause the common genetic kidney disorder
autosomal dominant polycystic kidney disease (ADPKD). It is unknown how these mutations …

Nanostructured biomimetics have recently shown great promise in the field of tissue
engineering. They can be used as nanoscaffolds and tailored at the molecular level. The …

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a major renal pathology
provoked by the deletion of PKD1 or PKD2 genes leading to local renal tubule dilation …

The extracellular matrix (ECM), a complex set of fibrillar proteins and proteoglycans,
supports the renal parenchyma and provides biomechanical and biochemical cues critical …