Multiple sclerosis (MS) is a neuroinflammatory disorder characterized by autoimmune-
mediated inflammatory lesions in CNS leading to myelin damage and axonal loss. MS is a …

The extracellular matrix (ECM) is earning an increasingly relevant role in many disease
states and aging. The analysis of these disease states is possible with the GWAS and …

The study of disease-pathway association in human diseases is a perennial focus of the
biomedical field. The association of diseases and pathways can help in the discovery of the …

Extracellular matrices are essential for cellular and organismal function. Recent genome-
wide and phenome-wide association studies started to reveal a broad spectrum of …

The past two decades of analytical efforts have highlighted how much more remains to be
learned about the human genome and, particularly, its complex involvement in promoting …

Intervertebral disc degeneration (IDD) is a common cause of low back pain and disability.
Standard treatment of IDD is conservative therapies and surgical treatment, that have some …

Intervertebral disc (IVD) degeneration (IDD) is a multifactorial physiological process which is
often associated with lower back pain. Previous studies have identified some molecular …

Despite the vast phenotypic differences observed across primates, their protein products are
largely similar to each other at the sequence level. We hypothesized that, since proteins …

Orphan diseases (ODs) are progressive genetic disorders, which affect a small number of
people. The principal fundamental aspects related to these diseases include insufficient …

Phenotypic data are critical for understanding biological mechanisms and consequences of
genomic variation, and are pivotal for clinical use cases such as disease diagnostics and …