After Edward Jenner established human vaccination over 200 years ago, attenuated
poxviruses became key players to contain the deadliest virus of its own family: Variola virus …

Since their initial expansion in human beings roughly seven decades ago in central Africa,
the HIV-1 pandemic strains have diversified extensively through mutation and …

The development of an effective human immunodeficiency virus type 1 (HIV-1) vaccine is
likely to depend on knowledge of circulating variants of genes other than the commonly …

A unique cohort of HIV-1-infected long term nonprogressors (LTNP) with normal CD4+ T cell
counts and< 50 copies/ml of plasma were prospectively recruited for study. HLA typing …

It is unclear why immunological control of HIV replication is incomplete in most infected
individuals. We examined here the CD8+ T cell response to HIV-infected CD4+ T cells in …

This book grew out of a scientific review, originally published in Microbiological Reviews. It
has been updated and expanded-now citing more than 2100 references (100 pages of the …

Summary Background The MRKAd5 HIV-1 gag/pol/nef subtype B vaccine was designed to
elicit T-cell-mediated immune responses capable of providing complete or partial protection …

Among nonneutralizing HIV-1 envelope antibodies (Abs), those capable of mediating
antibody-dependent cellular cytotoxicity (ADCC) activity have been postulated to be …

Vaccines in general and HIV vaccines in particular are focusing ever more on the induction
of cellular immunity specifically the generation of cytotoxic T cells (CTL). As progress is …

The functional status of circulating human immunodeficiency (HIV)-specific CD8 T cells in
chronically infected subjects was evaluated. By flow cytometry, only 5 of 7 subjects had …