Alzheimer's disease is the most common neurodegenerative disorder that can cause
dementia in elderly over 60 years of age. One of the disease hallmarks is oxidative stress …

Delirium is a clinical syndrome occurring in heterogeneous patient populations. It affects 45–
87% of critical care patients and is often associated with adverse outcomes including …

Deterioration of brain capillary flow and architecture is a hallmark of aging and dementia. It
remains unclear how loss of brain pericytes in these conditions contributes to capillary …

Accurate identification of brain function is necessary to understand the neurobiology of
cognitive ageing, and thereby promote well-being across the lifespan. A common tool used …

Ageing is accompanied by a steady decline in touch sensitivity and acuity. Conversely,
pleasant touch, such as experienced during a caress, is even more pleasant in old age …

Retinal microcirculation shares similar features with cerebral small blood vessels. Thus, the
retina may be considered an accessible 'window'to detect the microvascular damage …

Age-related blood-brain barrier (BBB) disruption and cerebromicrovascular rarefaction
contribute importantly to the pathogenesis of both vascular cognitive impairment and …

The population is ageing worldwide, thus increasing the burden of common age-related
disorders to the individual, society and economy. Cerebrovascular diseases (stroke …

China and the world are facing severe population aging and an increasing burden of age-
related diseases. Aging of the brain causes major age-related brain diseases, such as …

The prevalence of neurological/neurodegenerative diseases, such as Alzheimer's disease is
known to be increasing due to an aging population and is anticipated to further grow in the …