Artificial intelligence in cancer target identification and drug discovery

Y You, X Lai, Y Pan, H Zheng, J Vera, S Liu… - … and Targeted Therapy, 2022 - nature.com
Artificial intelligence is an advanced method to identify novel anticancer targets and discover
novel drugs from biology networks because the networks can effectively preserve and …

Microglial efferocytosis: diving into the Alzheimer's disease gene pool

C Romero-Molina, F Garretti, SJ Andrews, E Marcora… - Neuron, 2022 - cell.com
Genome-wide association studies and functional genomics studies have linked specific cell
types, genes, and pathways to Alzheimer's disease (AD) risk. In particular, AD risk alleles …

Co-regulatory networks of human serum proteins link genetics to disease

V Emilsson, M Ilkov, JR Lamb, N Finkel… - Science, 2018 - science.org
Proteins circulating in the blood are critical for age-related disease processes; however, the
serum proteome has remained largely unexplored. To this end, 4137 proteins covering most …

Gene co-expression analysis for functional classification and gene–disease predictions

S Van Dam, U Vosa, A van der Graaf… - Briefings in …, 2018 - academic.oup.com
Gene co-expression networks can be used to associate genes of unknown function with
biological processes, to prioritize candidate disease genes or to discern transcriptional …

Multiomics to elucidate inflammatory bowel disease risk factors and pathways

M Agrawal, KH Allin, F Petralia, JF Colombel… - Nature Reviews …, 2022 - nature.com
Inflammatory bowel disease (IBD) is an immune-mediated disease of the intestinal tract, with
complex pathophysiology involving genetic, environmental, microbiome, immunological and …

The role of regulatory variation in complex traits and disease

FW Albert, L Kruglyak - Nature Reviews Genetics, 2015 - nature.com
We are in a phase of unprecedented progress in identifying genetic loci that cause variation
in traits ranging from growth and fitness in simple organisms to disease in humans …

The IBD interactome: an integrated view of aetiology, pathogenesis and therapy

HSP De Souza, C Fiocchi, D Iliopoulos - … Reviews Gastroenterology & …, 2017 - nature.com
Crohn's disease and ulcerative colitis are prototypical complex diseases characterized by
chronic and heterogeneous manifestations, induced by interacting environmental, genomic …

How can synergism of traditional medicines benefit from network pharmacology?

H Yuan, Q Ma, H Cui, G Liu, X Zhao, W Li, G Piao - Molecules, 2017 - mdpi.com
Many prescriptions of traditional medicines (TMs), whose efficacy has been tested in clinical
practice, have great therapeutic value and represent an excellent resource for drug …

Functional variants in the LRRK2 gene confer shared effects on risk for Crohn's disease and Parkinson's disease

KY Hui, H Fernandez-Hernandez, J Hu… - Science translational …, 2018 - science.org
Crohn's disease (CD), a form of inflammatory bowel disease, has a higher prevalence in
Ashkenazi Jewish than in non-Jewish European populations. To define the role of …

The microbiome in allergic disease: current understanding and future opportunities—2017 PRACTALL document of the American Academy of Allergy, Asthma & …

YJ Huang, BJ Marsland, S Bunyavanich… - Journal of Allergy and …, 2017 - Elsevier
PRACTALL is a joint initiative of the American Academy of Allergy, Asthma & Immunology
and the European Academy of Allergy and Clinical Immunology to provide shared evidence …