The hippocampus has a pivotal role in learning and in the formation and consolidation of
memory and is critically involved in the regulation of emotion, fear, anxiety, and stress …

During the last decade the what, where and when (WWWhen) episodic-like memory (ELM)
task, which is based on the object recognition paradigm, has been utilized for the cognitive …

Aging is associated with cognitive decline in both humans and animals and of all brain
regions, the hippocampus appears to be particularly vulnerable to senescence. Age-related …

The prokaryotic adaptive immune system CRISPR/Cas9 has recently been adapted for
genome editing in eukaryotic cells. This technique allows for sequence-specific induction of …

N‐methyl‐D‐aspartate receptors (NMDARs) mediate slow excitatory postsynaptic
transmission in the central nervous system, thereby exerting a critical role in neuronal …

As the genomic basis for Down syndrome (DS), human trisomy 21 is the most common
genetic cause of intellectual disability in children and young people. The genomic regions …

Background Peripheral nerve injury can have long-term consequences including pain-
related manifestations, such as hypersensitivity to cutaneous stimuli, as well as affective and …

Alzheimer's disease (AD) in the early stages is characterized by memory impairment, which
may be attributable to synaptic dysfunction. Oxidative stress, mitochondrial dysfunction, and …

Activation of the NMDA receptor (NMDAR) has been proposed to be a key event responsible
for the structural changes that occur in neurons during learning and memory formation. It has …

It is postulated that disruptions of glutamatergic signalling may underlie the pathophysiology
of psychosis and schizophrenia. A strong body of evidence indicates that antagonism of the …