Alzheimer's disease (AD) is the most common type of dementia and is characterized by the
accumulation of amyloid (Aβ) plaques and neurofibrillary tangles in the brain. Much attention …

Store-operated Ca2+ entry (SOCE) is a ubiquitous Ca2+ signaling pathway that is
evolutionarily conserved across eukaryotes. SOCE is triggered physiologically when the …

Learning and memory require coordinated structural and functional plasticity at neuronal
glutamatergic synapses located on dendritic spines. Here, we investigated how the …

Alzheimer's disease (AD) is the most common type of neurodegenerative amyloid disorder
causing progressive cognitive decline and memory loss. A considerable number of …

Stromal interaction molecules (STIM) 1 and 2 are sensors of the calcium concentration in the
endoplasmic reticulum. Depletion of endoplasmic reticulum calcium stores activates STIM …

Emerging evidence indicates that Ca2+ is a vital factor in modulating the pathogenesis of
Alzheimer's disease (AD). In healthy neurons, Ca2+ concentration is balanced to maintain a …

Store-operated calcium entry (SOCE) is the flow of calcium ions (Ca 2+) into cells in
response to the depletion of intracellular Ca 2+ stores that reside predominantly in the …

The proper spatial arrangement of organelles underlies many cellular processes including
signaling, polarization, and growth. Despite the importance of local positioning, the precise …

Neurons possess a complex morphology spanning long distances and a large number of
subcellular specializations such as presynaptic terminals and dendritic spines. This …

Stromal interaction molecules (STIMs), including STIM1 and STIM2, are single-pass
transmembrane proteins that are located predominantly in the endoplasmic reticulum (ER) …