Animal models of human diseases that accurately recapitulate clinical pathology are
indispensable for understanding molecular mechanisms and advancing preclinical studies …

Alzheimer's disease (AD) is the most prevalent form of dementia which affects people older
than 60 years of age. In AD, the dysregulation of the amyloid-beta (Aβ) level leads to the …

This review is concerned with the role of fibrillization of the amyloid β (Aβ)-peptide in
Alzheimer's disease (AD). The perspective is that of a physical chemist, and one aim is to …

The kinesin, dynein, and myosin superfamily molecular motors have fundamental roles in
neuronal function, plasticity, morphogenesis, and survival by transporting cargos such as …

Amyloid precursor protein (APP) is an evolutionarily conserved transmembrane protein and
a well-characterized precursor protein of amyloid-beta (Aβ) peptides, which accumulate in …

The most common form of senile dementia is Alzheimer's disease (AD), which is
characterized by the extracellular deposition of amyloid β-peptide (Aβ) plaques and the …

Eukaryotic cells create internal order by using protein motors to transport molecules and
organelles along cytoskeletal tracks. Recent genomic and functional studies suggest that …

Life implies movement. Most forms of movement in the living world are powered by tiny
protein machines known as molecular motors. Among the best known are motors that use …

Inflammation is a defense reaction against diverse insults, designed to remove noxious
agents and to inhibit their detrimental effects. It consists of a dazzling array of molecular and …

Autophagy is the principal cellular pathway for degradation of long-lived proteins and
organelles and regulates cell fate in response to stress. Recently, autophagy has been …