Aging is a complex biological process that increases the risk of age-related cognitive
degenerative diseases such as dementia, including Alzheimer's disease (AD), Lewy Body …

Rationale Early life stress has been implicated in many psychiatric disorders ranging from
depression to anxiety. Maternal separation in rodents is a well-studied model of early life …

Early-life stress is a determinant of vulnerability to a variety of disorders that include
dysfunction of the brain and gut. Here we exploit a model of early-life stress, maternal …

Neurotrophic factors comprise a broad family of biomolecules–most of which are peptides or
small proteins–that support the growth, survival and differentiation of both developing and …

Recent studies have demonstrated a clear association between changes in the microbiota
and cognitive behavior. Intestinal dysbiosis, as modeled using GF mice (containing no …

Stress has long been associated with the development of neuropsychiatric and neurological
disorders. The effects of stress vary depending upon the age during which the stress is …

Purpose: Depression is one of the most prevalent, recurrent and life-threatening mental
illnesses. However, the precise mechanism underlying the disorder is not yet clearly …

Environmental enrichment (EE) was shown recently to accelerate brain development in
rodents. Increased levels of maternal care, and particularly tactile stimulation through licking …

The gestational state is a period of particular vulnerability to diseases that affect maternal
and fetal health. Stress during gestation may represent a powerful influence on maternal …

Early life is a period of unique sensitivity during which experience can confer enduring
effects on brain structure and function. During early perinatal life the quality of the …