Primary tumors actively and specifically prime pre-metastatic niches (PMNs), the future sites
of organotropic metastasis, preparing these distant microenvironments for disseminated …

Pulmonary fibrosis is a chronic progressive lung disease that steadily leads to lung
architecture disruption and respiratory failure. The development of pulmonary fibrosis is …

The lysyl oxidase family represents a promising target in stromal targeting of solid tumors
due to the importance of this family in crosslinking and stabilizing fibrillar collagens and its …

LOX (lysyl oxidase) and lysyl oxidase like-1–4 (LOXL 1–4) are amine oxidases, which
catalyze cross-linking reactions of elastin and collagen in the connective tissue. These …

Simple Summary To improve efficacy of solid cancer treatment, efforts have shifted towards
targeting both the cancer cells and the surrounding tumour tissue they grow in. The lysyl …

Fibrosis is a pathological state characterized by excessive deposition of the extracellular
matrix components leading to impaired tissue function in the affected organ. It results in …

Lysyl Oxidase Like 2 (LOXL2) belongs to the lysyl oxidase (LOX) family, which comprises
five lysine tyrosylquinone (LTQ)-dependent copper amine oxidases in humans. In 2003 …

Background Type 2 innate lymphoid cells (ILC2s) are relevant players in type 2 asthma.
They initiate eosinophil infiltration and airway hyperreactivity (AHR) through cytokine …

The discovery that primary tumors condition distant organ sites of future metastasis for
seeding by disseminating tumor cells through a process described as the pre-metastatic …

Cancer metastasis, the spread of disease from a primary to a distal site through the
circulatory or lymphatic systems, accounts for over 90% of all cancer related deaths. Despite …