The essential elements of Alzheimer's disease
Treatments for Alzheimer's disease (AD) directed against the prominent amyloid plaque
neuropathology are yet to be proved effective despite many phase 3 clinical trials. There are …
neuropathology are yet to be proved effective despite many phase 3 clinical trials. There are …
Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs
Abstract According to the Alzheimer Association Report (2017), Alzheimer's disease (AD) is
the 6th primary cause of death in the USA, which affects nearly 5.5 million people. In the …
the 6th primary cause of death in the USA, which affects nearly 5.5 million people. In the …
Role of oxidative stress in Alzheimer's disease
WJ Huang, XIA Zhang, WW Chen - Biomedical reports, 2016 - spandidos-publications.com
Alzheimer's disease (AD) is the most common cause of disability in individuals aged> 65
years worldwide. AD is characterized by the abnormal deposition of amyloid β (Aβ) peptide …
years worldwide. AD is characterized by the abnormal deposition of amyloid β (Aβ) peptide …
Metabolism and functions of copper in brain
IF Scheiber, JFB Mercer, R Dringen - Progress in neurobiology, 2014 - Elsevier
Copper is an important trace element that is required for essential enzymes. However, due
to its redox activity, copper can also lead to the generation of toxic reactive oxygen species …
to its redox activity, copper can also lead to the generation of toxic reactive oxygen species …
[HTML][HTML] Metallobiology and therapeutic chelation of biometals (copper, zinc and iron) in Alzheimer's disease: Limitations, and current and future perspectives
Background Alzheimer's disease (AD) is the most prevalent cause of cognitive impairment
and dementia worldwide. The pathobiology of the disease has been studied in the form of …
and dementia worldwide. The pathobiology of the disease has been studied in the form of …
Curcumin and its derivatives: their application in neuropharmacology and neuroscience in the 21st century
Curcumin (diferuloylmethane), a polyphenol extracted from the plant Curcuma longa, is
widely used in Southeast Asia, China and India in food preparation and for medicinal …
widely used in Southeast Asia, China and India in food preparation and for medicinal …
Bioinorganic chemistry of Alzheimer's disease
KP Kepp - Chemical reviews, 2012 - ACS Publications
Alzheimer's disease (AD) 1− 3 is the most common form of dementia (estimated∼ 50− 60%
of all cases), associated with loss of memory (in particular episodic memory), cognitive …
of all cases), associated with loss of memory (in particular episodic memory), cognitive …
Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides …
CC Willhite, NA Karyakina, RA Yokel… - Critical reviews in …, 2014 - Taylor & Francis
Aluminum (Al) is a ubiquitous substance encountered both naturally (as the third most
abundant element) and intentionally (used in water, foods, pharmaceuticals, and vaccines); …
abundant element) and intentionally (used in water, foods, pharmaceuticals, and vaccines); …
Mechanisms for copper acquisition, distribution and regulation
BE Kim, T Nevitt, DJ Thiele - Nature chemical biology, 2008 - nature.com
Copper (Cu) is a redox-active metal ion essential for most aerobic organisms. Cu serves as
a catalytic and structural cofactor for enzymes that function in energy generation, iron …
a catalytic and structural cofactor for enzymes that function in energy generation, iron …
Advancements in the development of multi-target directed ligands for the treatment of Alzheimer's disease
Alzheimer's disease (AD) is a multifactorial irreversible neurological disorder which results
in cognitive impairment, loss of cholinergic neurons in synapses of the basal forebrain and …
in cognitive impairment, loss of cholinergic neurons in synapses of the basal forebrain and …