Systemic sclerosis (SSc) is an idiopathic autoimmune disease with a heterogeneous clinical
phenotype ranging from limited cutaneous involvement to rapidly progressive diffuse SSc …

Fibrosis is a pathological process characterized by accumulation of fibrous connective tissue
in organs, leading to organ malfunction and failure. At the cellular level, tissue injury or …

Abstract Background Systemic sclerosis (SSc), a multi-organ disorder, is characterized by
vascular abnormalities, dysregulation of the immune system, and fibrosis. The mechanisms …

Angiotensin-converting enzyme inhibitors (ACEIs) can improve the fibrotic processes in
many internal organs. Recent studies have shown a relationship between ACEI with …

Background and Purpose Angiotensin‐converting enzyme (ACE), an important part of the
renin‐angiotensin system, is implicated in stimulating the fibrotic processes in the heart …

Trans-differentiation of quiescent hepatic stellate cells (HSC) to myofibroblasts is a hallmark
event in liver fibrosis. Previous studies have led to the discovery that myocardin-related …

The pathogenesis of many diseases is influenced by environmental factors which can affect
human genome and be inherited from generation to generation. Adverse environmental …

ABSTRACT Introduction Systemic sclerosis (SSc) is a systemic disease encompassing
autoimmunity, vasculopathy, and fibrosis. SSc is still burdened by high mortality and …

BACKGROUND: Elderly people often suffer from sleep disorders. Chamomile due to the
many health benefits such as sedation may be effective in improving sleep quality in elderly …

Objective The aim of the current study was to evaluate if methylation status of CpG sites of
interferon regulatory factor 7 (IRF7) promoter in peripheral blood mononuclear cells …