Axial loading in rodents provides a controlled setting for mechanical loading, because load
and subsequent strain, frequency, number of cycles and rest insertion between cycles, are …

Maintenance of skeletal integrity requires the coordinated activity of multinucleated bone-
resorbing osteoclasts and bone-forming osteoblasts. Osteoclasts form resorption lacunae on …

Abstract Toll-like receptor-4 (TLR4) has been implicated in the development and
progression of diabetic osteoporosis. However, the mechanisms underlying TLR4-regulated …

Osteoporosis is caused by enhanced bone resorption and relatively reduced bone
formation. There is an unmet need to develop new agents with both antiresorptive and …

In mature bone, NGF is produced by osteoblasts following mechanical loading and signals
through resident sensory nerves expressing its high affinity receptor, neurotrophic tyrosine …

Aberrant NF-κB signaling fuels tumor growth in multiple human cancer types including both
hematologic and solid malignancies. Chronic elevated alternative NF-κB signaling can be …

NF-κB has been reported to both promote and inhibit bone formation. To explore its role in
osteolineage cells, we conditionally deleted IKKα, an upstream kinase required for non …

Aims Osteoarthritis (OA) is a common degenerative joint disease. The osteocyte
transcriptome is highly relevant to osteocyte biology. This study aimed to explore the …

Osteoporosis is often known as a silent disease and is estimated to affect approximately 200
million people across the globe. It is projected that by 2050, the economic burden of …

NF-κB has been reported to both promote and inhibit bone formation. To further explore its
role in osteolineage cells, we conditionally deleted IKKα, an upstream kinase required for …