Within each synovial joint, the articular cartilage is uniquely adapted to bear dynamic
compressive loads and shear forces throughout the joint's range of motion. Injury and age …

Articular cartilage has obvious and fundamental roles in joint function and body movement.
Much is known about its organization, extracellular matrix, and phenotypic properties of its …

Collagen V is a regulatory fibril-forming collagen that forms heterotypic fibrils with collagen I.
Deletion of collagen V in the mouse is associated with a lack of fibril assembly in the …

Cartilage tissue is characterized by zonal organization with gradual transitions of
biochemical and mechanical cues from superficial to deep zones. We previously reported …

Introduction Age is an important factor in the development of osteoarthritis. Microarray
studies provide insight into cartilage aging but do not reveal the full transcriptomic …

Background Bone marrow (BM)-and adipose tissue (AT)-derived mesenchymal stromal cells
(MSCs) have shown potential as cell-based therapies for cartilage and bone injuries and are …

Background: Bone marrow (BM)-and adipose tissue (AT)-derived mesenchymal stem cells
(MSCs) are used increasingly for autologous cell therapy in equine practice to treat …

Mammalian cartilage is a complex and developmentally important tissue type. Outside the
mammalian lineage, cartilage may persist as an adult tissue, which shows a much wider …

Background: Articular cartilage undergoes substantial age-related changes in molecular
composition, matrix structure, and mechanical properties. These age-related differences …

Human articular chondrocytes (hACs) are scarce and lose their chondrogenic potential
during monolayer passaging, impeding their therapeutic use. This study investigated (a) the …