Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

BACKGROUND Infertility affects between 10 and 16% of couples worldwide. Twenty to 30%
of cases of infertility are due to a male factor, 20–35% to a female factor, and 25–40% are …

In mammals, sperm–oocyte fusion initiates Ca2+ oscillations leading to a series of events
called oocyte activation, which is the first stage of embryo development. Ca2+ signaling is …

BACKGROUND Total fertilization failure (TFF) is the failure of all metaphase II oocytes to
fertilize in ART cycles. The phenomenon represents a known cause of infertility, affecting 1 …

Abstract Phosphoinositide-specific phospholipase Cs (PLCs) are expressed in all
mammalian cells and play critical roles in signal transduction. To obtain a comprehensive …

In mammals, the sperm activates the development of the egg by triggering a series of
oscillations in the cytosolic-free Ca 2+ concentration (Ca 2+ i). The sperm triggers these …

BACKGROUND Oocyte activation deficiency (OAD) is attributed to the majority of cases
underlying failure of ICSI cycles, the standard treatment for male factor infertility. Oocyte …

Freshly ejaculated spermatozoa are incapable or poorly capable of fertilizing an oocyte. The
fertilization aptness of spermatozoa depends on the appropriate and time‐dependent …

Calcium (Ca2+) signals initiate egg activation across the animal kingdom and in at least
some plants. These signals are crucial for the success of development and, in the case of …

OBJECTIVE: To determine the effect of infertility-linked sperm phospholipase Cζ (PLCζ)
mutations on their ability to trigger oocyte Ca2+ oscillations and development, and also to …