Highlights•B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is currently treated by
risk-adapted intensive chemotherapy•Genome-wide genomic analyses have uncovered the …

There are important breakthroughs in the treatment of paediatric acute lymphoblastic
leukaemia (ALL) since 1950, by which the prognosis of the child majority suffered from ALL …

Background Alterations of FLT3 are among the most common driver events in acute
leukaemia with important clinical implications, since it allows patient classification into …

Background We aimed to investigate the frequencies and the association with
genetic/cytogenetic abnormalities as well as prognostic relevance of RAS pathway …

Acute lymphoblastic leukemia (ALL) is the most common cancer in children. Numerous
studies have shown that microRNAs (miRNAs) could play a role in this disease. Nowadays …

Background and Aims The biological characterization of childhood acute myeloid leukemia
(c-AML) is an important outcome predictor. In Brazil, very little is known about the frequency …

Introduction Acute lymphoblastic leukemia (ALL) is the most common childhood cancer in
the world, which is associated with a wide spectrum of factors that play an important role in …

Introduction There is consistent evidence that FLT3 may be a driver gene in B-ALL and that
selected cases may benefit from the use of FLT3 inhibitors. Our study was conducted to …

PTPN11 mutation, a RAS signaling pathway mutation, is associated with MLL translocations
in acute leukemia. A girl with MLL/AF10 AML was found to carry PTPN11G503A. To study …

The RAS genes are importantly implicated in oncogenesis and are frequently mutated in
childhood acute lymphoblastic leukemia. This study is the first to our knowledge, to …