Proteasomes are the principal molecular machines for the regulated degradation of
intracellular proteins. These self-compartmentalized macromolecular assemblies selectively …

Archaea are major contributors to biogeochemical cycles, possess unique metabolic
capabilities, and resist extreme stress. To regulate the expression of genes encoding these …

INTRODUCTION Eukaryotes likely arose from a symbiotic partnership between an archaeal
host and an alpha-proteobacterium, giving rise to the cell body and the mitochondria …

Lipopolysaccharide (LPS) could induce adverse birth outcomes by evoking inflammation.
We investigated the effect and mechanism of docosahexaenoic acid (DHA) on LPS-induced …

Formation of gametes in the malaria parasite occurs in the midgut of the mosquito and is
critical to onward parasite transmission. Transformation of the male gametocyte into …

Site-specific incorporation of distinct non-canonical amino acids into proteins via genetic
code expansion requires mutually orthogonal aminoacyl-tRNA synthetase/tRNA pairs …

Throughout evolution, living organisms, including microorganisms, have developed survival
strategies to live in harsh environmental conditions. The unfavorable environmental …

Phytoene synthase (PSY) converts two molecules of geranyl-geranyl diphosphate to
phytoene, the key regulatory step in carotenogenesis. However, post-translational …

While protein ubiquitination was long believed to be a truly eukaryotic feature, recently
sequenced genomes revealed complete ubiquitin (Ub) modification operons in archaea …

Oxidative stress adaptation strategies are important to cell function and are linked to cardiac,
neurodegenerative disease, and cancer. Representatives of the Archaea domain are used …