Cardiovascular diseases remain the leading cause of death worldwide, with pathological
fibrotic remodeling mediated by activated cardiac myofibroblasts representing a unifying …

This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …

Since the discovery nearly 60 years ago, cAMP is envisioned as one of the most universal
and versatile second messengers. The tremendous feature of cAMP to tightly control highly …

There are many downstream targets of mitogen-activated protein kinase (MAPK) signalling
that are involved in neuronal development, cellular differentiation, cell migration, cancer …

cAMP is a universal second messenger that plays central roles in cardiovascular regulation
influencing gene expression, cell morphology, and function. A crucial step toward a better …

Fibrosis, the result of excess deposition of extracellular matrix (ECM), in particular collagen,
leads to scarring and loss of function in tissues that include the heart, lung, kidney and liver …

The two branches of the autonomic nervous system (ANS), adrenergic and cholinergic, exert
a multitude of effects on the human myocardium thanks to the activation of distinct G protein …

Chronic degenerative inflammatory diseases, such as chronic obstructive pulmonary
disease and Alzheimer's dementia, afflict millions of people around the world, causing death …

The major physiological effects of cAMP in mammalian cells are transduced by two
ubiquitously expressed intracellular cAMP receptors, protein kinase A (PKA) and exchange …

Phosphodiesterases (PDEs) are a superfamily of enzymes that hydrolyze cyclic nucleotides,
including cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate …