The mucus clearance system is the dominant mechanical host defense system of the human
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …

Gene therapy is now being applied to the treatment of a wide variety of acquired and
inherited diseases. One of the rate-limiting steps for successful gene therapy is the efficiency …

A human bronchial xenograft model was used to characterize the molecular basis for the
previously described defect in bacterial killing that is present in the cystic fibrosis (CF) lung …

An important limitation that has emerged in the use of adenoviruses for gene therapy has
been loss of recombinant gene expression that occurs concurrent with the development of …

Abstract The 55-kilodalton (kDa) protein from the E1B-region of adenovirus binds to and
inactivates the p53 gene, which is mutated in half of human cancers. We have previously …

To evaluate the potential of direct transfer of cystic fibrosis transmembrane conductance
regulator (CFTR) cDNA for the treatment of cystic fibrosis (CF), we administered an E1 …

The risk of atherosclerosis, a leading cause of cardiovascular disease and death, is
inversely related to plasma levels of high-density lipoprotein (HDL) cholesterol, although the …

Recombinant adenoviruses are an attractive vehicle for gene therapy to the lung in the
treatment of cystic fibrosis (CF). First-generation viruses deleted of E1a and E1b transduce …

We have administered a recombinant adenovirus vector (Ad CFTR) containing the normal
human CFTR cDNA to the nasal and bronchial epithelium of four individuals with cystic …

The therapeutic efficacy of adenovirus-mediated herpes simplex virus thymidine kinase
(HSV-tk) gene transduction of rat C6 glioma cells followed by ganciclovir (GCV) …