In recent years, accumulating evidence has elucidated the role of lysosomes in dynamically
regulating cellular and organismal homeostasis. Lysosomal changes and dysfunction have …

Tumors are like new organs and are made of multiple cell types and components. The tumor
competes with the normal microenvironment to overcome antitumorigenic pressures. Before …

Myeloid cells can restrain antitumor immunity by metabolic pathways, such as the
degradation of l-arginine, whose concentrations are regulated by the arginase 1 (ARG1) …

Proteases, including intracellular proteases, play roles at many different stages of malignant
progression. Our focus here is cathepsin B, a lysosomal cysteine cathepsin. High levels of …

The microenvironment is known to critically modulate tumor progression, yet its role in
regulating treatment response is poorly understood. Here we found increased macrophage …

Background Cysteine cathepsins are normally found in the lysosomes where they are
involved in intracellular protein turnover. Their ability to degrade the components of the …

Coined in the late eighties, the term “angiogenic switch” refers to a time-restricted event
during tumor progression where the balance between pro-and anti-angiogenic factors tilts …

Lysosomes are the key degradative compartments of the cell. Lysosomal cathepsins, which
are enclosed in the lysosomes, help to maintain the homeostasis of the cell's metabolism by …

The tumour microenvironment regulates tumour progression and the spread of cancer in the
body. Targeting the stromal cells that surround cancer cells could, therefore, improve the …

Lysosomes, with their arsenal of degradative enzymes are increasingly becoming an area of
interest in the field of oncology. The changes induced in this compartment upon …