A high-fat diet (HFD) induces changes in gut microbiota leading to activation of pro-
inflammatory pathways, and obesity, as a consequence of overnutrition, exacerbates …

Traditional chemotherapy relies on the premise that rapidly proliferating cancer cells are
more likely to be killed by a cytotoxic agent, but in reality, the long-standing problem of …

Globally, there were 14.1 million new cancer diagnoses and 8.2 million cancer deaths in
2012. For many cancers, conventional therapies are limited in their successes and an …

Background PUFAs are important molecules for membrane order and function; they can
modify inflammation-inducible cytokines production, eicosanoid production, plasma …

Cyclooxygenase (COX)-2 is a pro-inflammatory immediate early response protein,
chronically up-regulated in many pathological conditions. In autoimmune diseases, it is …

Over the centuries, plant extracts have been used to treat various diseases. Until now,
natural products have played an important role in anticancer therapy as there are more than …

n− 3 polyunsaturated fatty acids exert growth-inhibitory and pro-apoptotic effects in colon
cancer cells. We hypothesized that the anti-apoptotic glucose related protein of 78kDa …

Chemotherapy is standard treatments for many malignancies. However, in most cases, this
method is not able to induce apoptosis and in many cases, with cancer recurrence, leads to …

Cancer associated fibroblasts (CAFs) are responsible for tumor growth, angiogenesis,
invasion, and metastasis. Matrix metalloproteinase (MMP)-9 secreted from cancer stroma …

Omega-3 (n-3) fatty acids are dietary long-chain fatty acids with an array of health benefits.
Previous research has demonstrated the growth-inhibitory effect of n-3 fatty acids on …